AXON

Issue Nº 04 September 2026 All issues

Faster, Not Smarter. Dr. Rod Oskouian beside an engraved anatomical plate of a human hand. AXON, by Rod J. Oskouian, MD, FAANS

Caffeine Makes You Faster, Not Smarter

I agreed on camera that more stimulation is not better. Then I read the trials, and what they actually show is stranger than that.

Adrinks founder explained to me why her energy drink carries less caffeine than the cans beside it on the shelf, where most sit at two hundred milligrams and some go to three hundred. Her argument was that more stimulation is not better, and I said much the same thing myself.

Then I went and read the trials properly. The dose that matters is not the number printed on the can. It is the number you set yesterday.

Plate I Why the molecule fits
The chemical structures of caffeine and adenosine drawn side by side, showing that both are built on the same fused double ring of carbon and nitrogen atoms.
Fig. 1. Caffeine works because it resembles adenosine, the molecule that builds up as the brain spends fuel and makes tiredness feel like tiredness. Close enough to occupy the same docking point. Not close enough to switch it on.3 Caffeine and adenosine, public domain, via Wikimedia Commons.

The trial that put both kinds of drinker in the same room

Almost every caffeine study has the same flaw. To test the drug you have to take it away first, and taking it away from a daily drinker makes that person worse than they started, so the study ends up measuring withdrawal and calling it caffeine.

One trial in Bristol got around that by splitting three hundred and sixty nine adults two ways at once: some drank caffeine daily, others barely touched it at under forty milligrams a day, and then each group was given either caffeine or a dummy.

Four groups, one afternoon. The daily drinkers on the dummy came last on almost everything, and when those same people were given caffeine they climbed back to roughly where the near abstainers already sat with nothing in them. The authors called it nearly complete tolerance.3

What wears off, and what never does

Here is the part that does not get printed, and it is the reason I wanted to write this. Caffeine’s effects do not wear off as a block. They come apart.

Finger tapping speed rose by about six taps in thirty seconds, and it rose by almost exactly the same amount in the daily drinkers as in the near abstainers. Years of habit did nothing to it. Alertness went the other way entirely, and there the daily drinkers were close to fully tolerant.3

One honest correction goes with that. On reaction time the caffeinated daily drinkers did not merely climb back level with the near abstainers, they came out slightly ahead, because the speeding effect stacks on top of the withdrawal being lifted.3

Year Study Finding
2010 Rogers et al. Neuropsychopharmacology Ratings only, no performance tasks. Daily drinkers given a dummy lost alertness and got headaches. Caffeine did not lift alertness in people who barely drink it.
2013 Rogers et al. Psychopharmacology The same Bristol volunteers with the full task battery. Tapping rose by the same amount in both groups. Alertness was nearly fully tolerant.
2013 Smith et al. J Psychopharmacol Washed regular drinkers out for a whole week, the design the other side asked for. Attention still improved.
2026 Sevenoaks et al. Eur J Neurosci Three groups, and no effect on mood or thinking. Twenty people per group is too few to settle anything.

These do not disagree. Two are one trial reported twice, one is the camp that washed people out for a week, and the last is a 2026 study too small to settle it either way.

The mechanism explains why the two effects part company, and it is not the one most people have been given.

  1. You spend fuel and a molecule builds up Adenosine accumulates through the waking day. Landing on its receptors is what tiredness is.
  2. Caffeine takes the seat without sitting down Close enough in shape to occupy the same docking point, not close enough to switch it on. The signal is blocked. The tiredness underneath is not.
  3. The brain adapts to the blockade Block a system every day and it adjusts. The sleepiness pathway adjusts. The motor one does not.
  4. Morning arrives with a deficit The first cup now has work to do before it can do anything else, and most of what it feels like is that work.
  5. What survives is speed, not clarity Both camps agree the hands get quicker. Whether the mind does is still being argued.3
Fig. 2. The direct adenosine measurements come from animal work in one region of the brain. The human evidence for this chain is indirect.

Where this gets ahead of the evidence

“More caffeine, more focus.”

Too simple

Above a moderate dose the extra mostly buys anxiety and a faster hand, not a clearer head. How much anxiety depends partly on a gene, and the people most sensitive to it drink more coffee, not less.

“So my coffee does nothing at all.”

Overstated

That goes too far. One group washed regular drinkers out for a full week, which is the design the tolerance camp demanded, and attention still improved. Most of the morning lift is withdrawal lifting. Most is not all.2

“I skipped a morning, so I know.”

Not a test

Withdrawal peaks somewhere between twenty and fifty one hours and can run for days. A skipped morning measures your withdrawal, not your caffeine. A real answer needs a week.

Caffeine reliably makes a tired hand quick. Whether it makes the mind clearer is a question thirty years of trials have still not closed.

References

  1. Rogers PJ, Hohoff C, Heatherley SV, et al. Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption. Neuropsychopharmacology, 2010
  2. Smith AP, Christopher G, Sutherland D. Acute effects of caffeine on attention: a comparison of non-consumers and withdrawn consumers. J Psychopharmacol, 2013
  3. Rogers PJ, Heatherley SV, Mullings EL, Smith JE. Faster but not smarter: effects of caffeine and caffeine withdrawal on alertness and performance. Psychopharmacology, 2013
  4. Sharma K, Kumar A, Gupta R, et al. Caffeine and attentional control in healthy older adults. Psychopharmacology, 2022
  5. Weippert M, Behrens M, Mau-Moeller A, et al. No effects of caffeine on cycling to exhaustion and perceptual responses in non-caffeine-restricted subjects. J Int Soc Sports Nutr, 2025
  6. Sevenoaks T, Wolfe R, Woods RL, et al. The effect of caffeine consumption and acute withdrawal on resting-state brain connectivity, mood and cognition. Eur J Neurosci, 2026

Figure. Caffeine and adenosine, public domain, via Wikimedia Commons.

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